- Beverly A. Purnell
After release of ova from the ovary, female germ cells are transported to the uterus through the oviduct or fallopian tubes. Various factors influence transit, including cilia, muscle contractions, and signaling molecules. Many mammalian species display temporary pausing and release, described as “valve-like tubal locking,” as ova transit the oviduct, and this arrest may assist in fertilization. However, ova are occasionally inappropriately stalled in the oviduct, and an ectopic pregnancy can result if they are fertilized by sperm. Bianchi et al. identified the oviduct-expressed gene adhesion G protein–coupled receptor D1 (Adgrd1) as being important for mouse embryo transport, in particular the restraining mechanism during embryo transit. When the gene is defective, fluid flow in the oviduct is altered and embryos become retained in the oviduct ampulla.
Nat. Commun. 12, 1251 (2021).
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