- Stella M. Hurtley
The idea that the immune and nervous systems can take a coordinated approach to potential harms is beginning to win traction. The lymph nodes constantly monitor lymph draining from peripheral tissues for potential pathogens. Using a variety of techniques, Huang et al. mapped sensory neuronal, immune, and stromal components of skin-draining lymph nodes in mice. They found sensory neurons at the lymph node periphery, poised to monitor inflammation-induced mechanical, chemical, and cellular changes. The sensory neurons were predominantly found to represent peptidergic nociceptors. The lymph node–innervating neurons were able to respond to inflammatory signals, potentially through communication with other lymph node–resident cell types. Lymph node stromal cells exhibited the highest potential for interaction with local sensory fibers. Stimulating the local sensory neurons elicited responses from lymphatic endothelial cells, blood endothelial cells, nonendothelial stroma, and certain populations of innate leukocytes. The identification of sensory neurons that innervate lymph nodes reveals a sensory neuronstroma axis likely to play a role in regulating responses to infection and inflammation.
Cell 10.1016/j.cell.2020.11.028 (2020).
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